We examine an extension of the Two-Higgs Doublet Model with a real gauge-singlet scalar Dark Matter candidate. This is the minimal Standard Model extension that allows for both Dark Matter and additional CP violation in the scalar sector. We have studied constraints on this model from the most recent LHC data together with Planck and direct Dark Matter searches (XENON/LUX/CRESST/CDMS). Invisible decays of light and heavy scalars have also been investigated.